Now, after 14 years of dedicated research and 265 clinical trials, Helena Rubinstein succeeded in designing a cream with an unprecedented 50% concentration of Pro-Xylane™. An exciting new addition to the Replasty range!
What makes Age Recovery Night 50PX so special?
All lies within Helena Rubinstein’s emblematic molecule, Pro-Xylane™, protected by 66 exclusive patents. This isn't just any ingredient; it's the very core of cellular repair and age recovery:
- Accelerated Skin Repair: Pro-Xylane™ is clinically proven to speed up the healing process of the skin barrier and epidermal wounds.
- Boosted Cellular Recovery: It stimulates the skin's innate ability to repair itself from within.
- Collagen & Matrix Reinforcement: This powerful molecule boosts collagen production and reinforces the skin's vital matrix, which is crucial for firmness and resilience.
- Unrivaled Purity & Efficacy: Our Pro-Xylane™ is six times purer than other derivatives* on the market and is scientifically proven to be five times more effective in stimulating skin repair and targeting signs of aging.
In Age Recovery Night 50PX, Helena Rubinstein’s scientist achieved an unprecedented concentration of 50% Pro-Xylane™.
*ingredients which share the same ingredient name (hydroxypropyl tetrahydropirantriol)
A Masterpiece of Formulation Prowess
Working with Pro-Xylane™ at such a high concentration is a challenge due to its inherent stickiness. Yet, Helena Rubinstein’s scientists have achieved to incorporate 50% dose while maintaining an ultra-luxurious, feather-light texture. This was made possible by a revolutionary "sixth step" in the inverse formulation process, utilizing exclusive micron-sized droplets of Pro-Xylane™ that are gradually blended into the formula, drop by drop.
This innovative water-in-oil "Black Bandage Technology™" ensures not only a distinct and exquisite sensory experience but also optimal efficacy. The oil-based external phase boasts excellent bio-affinity with the skin's natural lipid barrier, facilitating the deep penetration of Pro-Xylane™ into the skin's innermost layers: It reaches deep skin layers 6 times faster, and a high quantity is diffused after 24h within the skin. The formulation prowess improves the skin's absorption of a 50% Pro-Xylane™ concentration by up to five times than pure Pro-Xylane™ and boosts its overall efficacy.
Boosted penetration of Pro-Xylane™ thanks to Bandage Cream Technology
50% Pro-Xylane™ in Bandage Cream Technology
Pure Pro-Xylane™
What’s the difference between Age Recovery Night cream 30PX and Age Recovery Night 50PX cream?
While Replasty Age Recovery Night 30PX plumps, firms and smoothes to combat early signs of aging, Replasty Age Recovery Night 50PX targets the most stubborn aging signs: it lifts and reshapes the skin’s contours from deep within, making it ideal for skin that is losing definition.
Inspired by Laclinic-Montreux's medical insights, Replasty Age Recovery Night 50PX works to restructure the skin for its deepest reconstruction, addressing 5 key dimensions:
- Relieve: Soothes inflammation to calm irritation, redness, dryness, and dullness, promoting a clearer, more radiant complexion.
- Retexturize: Restores the skin's metabolism and stimulates its natural repair ability, improving texture, smoothing roughness, and minimizing the appearance of large pores and other irregularities.
- Rebuild: Reinforces the skin's defensive barrier and rebuilds the epidermis, plumping skin, and counteracting volume loss, fine lines, and thinning.
- Redensify: Strengthens the dermal-epidermal junction (DEJ) and improves skin elasticity, reducing sagging and wrinkles.
- Remodel: Helps remodel the dermis, firming up skin contours in the neck and chin area for a more defined jawline.
What do 50% of Pro-Xylane™ concretely do within my skin?
The 50% concentration of Pro-Xylane™ was proven to act at 5 different levels in skin (ex-vivo test**:
- Inflammation relief with a reduction of IL-1alpha (crucial pro-inflammatory cytokine)
- Metabolic repair with augmentation of the Acotinase production (a crucial enzyme that senses and combats oxidative stress)
- Epidermal reconstruction with augmentation of the production of Filaggrin, Syndecan and Collagen XIII, all involved in skin building or repair
- Dermo-epidermal Junction densification with increase in Perlecan, and 3 different types of collagens, all responsible for structural integrity of the skin's basement membrane
- Dermal Remodeling with augmentation of GAGs (both neutral and acidic) as well as 7 different types of collagens
**Human skin explants from a 44 y.o woman with a phototype II (according to Fitzpatrick skin type classification)
Redensify skin – Collagen IV synthesis
Control
50% Pro-Xylane™ in a Bandage Cream Technology
+48% COLLAGEN IV
What are the benefits I can expect from 50% Pro-Xylane™ bandage cream?
The effects of 50% Pro-Xylane™ observed at biological level translate into remarkable efficacy at clinical level.
Clinical tests reveal that:
- Instantly
- Skin is rested**,
- Skin is soothed**,
- Dryness is corrected**,
- Skin is repaired (within 1 hour)*. - Overnight:
- Reduction in redness**,
- Improved smoothness**,
- More radiant complexion**. - After 2 Weeks:
- Skin is plump and bouncy**,
- Texture is more even**,
- Visibility of fine lines is reduced**. - After 1 Month:
- Skin felt tightened**,
- Pore visibility is decreased by 29%***
- Nasolabial folds is decreased by 15%***,
- Uplifting effect**,
- Skin is strengthened**. - After 1 Jar:
- Significant improvements in neck sagging***,
- Pore visibility is decreased by 51%***,
- +39% Improvement in the lower part of the face/jawline***,
- Nasolabial fold decrease by 35%***,
- More defined chin (-22% chin withering)***,
- -8% Cheek fold decrease****.
Visible sagginess reduction with 50% Pro-Xylane™ Bandage Cream
Day 0
Control
After 1 month
Age Recovery Night 50PX
After 1 jar
Age Recovery Night 50PX
* TEWL on 24 women
** Consumer test on 84 Asian consumers
*** Clinical test on 47 Asian women
**** Instrumental test on 40 women 4h after application
Beyond anti-aging, effective Aesthetic Procedure ally
Replasty Age Recovery Night 50PX builts on the 15 years of proven efficacy both before and after cosmetic procedures. Discover more about its efficacy when combined with Microfocused Ultrasound here.
Audrey Gueniche
– Scientific Director
Audrey GUENICHE is a Doctor in Pharmacy and has a PhD in skin biology. She has a distinguished career of over three decades at L’Oréal in Research and Innovation. Her scientific contributions have been in the areas of topical and food supplements of skin, scalp, hair health and beauty. Audrey’s experience is extensive: from vitro to clinical trials, to open innovation and development. She has published over 130 papers in peer-reviewed journals, presented in 80 international congresses and, additionally, has been recognized and guest speaker in 50 plenary conferences. By embracing an innovative mindset, Audrey is passionate in finding new areas to promote actives and formulas, prove new claims and scientific communications, and reinvent evaluations. As HELENA RUBINSTEIN’s Scientific Director, Audrey pursues the brand’s long-standing avant-garde research and science.
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