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Helena Rubinstein Powercell Skinmunity  [EXO] green bottle alongside a laboratory glass ampoule and applicator.

Beyond Injections: Amplifying Skinboosters Benefits with Exosome Skincare

Skinbooster injections have emerged as a revolution in aesthetic medicine for restoring skin vitality. Unlike traditional fillers, these micro-injections utilize a composite solution of hyaluronic acid, associated with vitamins, antioxidants, and amino acids [1]. This treatment targets deep dehydration, loss of plumpness, and the appearance of fine lines.

While aesthetic procedures deliver targeted structural results, Helena Rubinstein avant-garde range and formulas operate at the skin's cellular level. They target essential cellular mechanisms to restore skin youthfulness from within. Combining the targeted precision of Skinbooster injections with this advanced cellular expertise creates the ultimate synergy to enhance and prolong procedure outcomes.
Creation Date:
Update Date: 13 Aug 2026


How do Skinboosters work?


Skinbooster injections act as a powerful biological catalyst to restore skin vitality and quality. This procedure delivers a composite solution of low cross-linked hyaluronic acid and amino acids directly into the dermal layer [1] to offer:

  • Intense Rehydration: Hyaluronic acid possesses an exceptional water-binding capacity. By instantly replenishing the dermal water reservoir, it restores skin suppleness, plumps tissue, smoothes surface roughness, and gives a radiant complexion ideal for a glow boosting routine.
  • Collagen Stimulation: The physical introduction of hyaluronic acid stretches the extracellular matrix. Fibroblasts sense this mechanical signal, triggering vital synthesis pathways. Amino acids act as essential building blocks for protein synthesis, fueling these fibroblasts to construct new, high-quality collagen and elastin fibers. This dual action provides structural support, visibly smoothing fine lines and boosting skin resilience.

Clinically, this procedure alone enhances hydration, refines skin texture, and minimizes the appearance of fine lines.

What to pair Skinboosters with?


“Modern high-intensity lifestyles generate a state of skin Burnout degrading skin quality and accelerating first signs of aging [2]. What we observe at the cellular level is that this condition progressively overwhelms the skin's intrinsic youth recovery mechanisms and triggers a profound loss of cell responsiveness.”

— Dr. Audrey Gueniche, Helena Rubinstein Global Scientific Director.

Skinboosters excel at treating external signs of skin fatigue. However, achieving a true, long-lasting transformation requires targeting the biological root of cellular exhaustion. Pairing clinical injections with Helena Rubinstein's avant-garde innovation, Powercell Skinmunity [EXO] Serum, creates an unparalleled synergy. While micro-injections physically rehydrate and replump the dermis, this exosome skincare, biologically reactivates cellular responsiveness. Know more here.



Helena Rubinstein Powercell Skinmunity [EXO] serum bottle surrounded by lab vials with green skin-rejuvenating formula


Maximizing Skinboosters outcomes


The synergy between Skinboosters and Powercell Skinmunity [EXO] Serum was validated in a clinical study on 40 Chinese women, aged from 25 to 45 years old [3]:

Boosted Efficacy: Within seven days, the protocol associated with Powercell Skinmunity [EXO] Serum, compared to a neutral cream, delivers a x4.1 improvement in fine lines, a x2.7 reduction in tactile roughness, and a x2.8 increase in radiance, counteracting lackluster skin.



Synergistic efficacy of Skinbooster injections with Powercell Skinmunity [EXO] Serum on wrinkles (3D Topography: the greener, the smoother).

skin surface scan   3D topography
macro texture imaging

Day 0

skin surface scan   3D topography
macro texture imaging

Day 28



Accelerated Recovery & Minimized Side Effects: Just one-hour post-procedure, 95% of subjects felt instantly soothed. The protocol significantly minimized post-injection reactions, with 80% of subjects reporting reduced swelling and 75% experiencing fewer "small bumps" at injection sites.



Synergistic efficacy of Skinbooster injections with Powercell Skinmunity [EXO] Serum, Anti-aging efficacy on smoothness.

Close-up of cheek skin texture at Day 0 before Powercell Skinmunity [EXO] serum and Skinbooster protocol

Day 0

Visible smoother cheek texture and refined skin at Day 28 after Powercell Skinmunity [EXO] serum and Skinbooster protocol

Day 28



Additional Results: By day 28, the synergy of the procedure associated with Powercell Skinmunity [EXO] Serum achieved benefits unattainable by the procedure alone, including a +26.13% increase in skin homogeneity.

Inspired by the plumping and smoothing effects of Skinboosters, Powercell Skinmunity [EXO] Serum replicates this tactile transformation daily. Combined with clinical injections, this alliance reaches a new dimension. By restoring intercellular communication, the protocol durably anchors treatment benefits while reducing side effects. This biological synergy drives profound youth recovery delivering a significant reduction of aging signs, boosting cell renewal and hydration. It extends aesthetic efficacy, leading 95% of users to wish to postpone their next injection session.



References


[1] Kyu-Ho Yi et al. Skin boosters: Definitions and varied classifications. Skin Res Technol. 2024;30: e13627.

[2] Passeron T. Clinical and biological impact of the exposome on the skin. J Eur Acad Dermatol, 2020.

[3] Clinical study conducted on 40 Asian women (aged 25-45) after one Skinbooster injection (HA & AA composite solution) — Twice-daily application of Powercell Skinmunity [EXO] Serum vs neutral cream for 28 days.



Audrey Gueniche– Scientific Director Image

Audrey Gueniche
– Scientific Director


Audrey GUENICHE is a Doctor in Pharmacy and has a PhD in skin biology. She has a distinguished career of over three decades at L’Oréal in Research and Innovation. Her scientific contributions have been in the areas of topical and food supplements of skin, scalp, hair health and beauty. Audrey’s experience is extensive: from vitro to clinical trials, to open innovation and development. She has published over 130 papers in peer-reviewed journals, presented in 80 international congresses and, additionally, has been recognized and guest speaker in 50 plenary conferences. By embracing an innovative mindset, Audrey is passionate in finding new areas to promote actives and formulas, prove new claims and scientific communications, and reinvent evaluations. As HELENA RUBINSTEIN’s Scientific Director, Audrey pursues the brand’s long-standing avant-garde research and science.

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